Impaired Toll-like receptor 8-mediated IL-6 and TNF-α production in antigen-presenting cells from patients with X-linked agammaglobulinemia

被引：67

作者：

Sochorova, Klara

Horvath, Rudolf

Rozkova, Daniela

Litzman, Jiri

Bartunkova, Jirina

Sediva, Anna

Spisek, Radek

机构：

[1] Charles Univ Prague, Sch Med 2, Inst Immunol, Prague 5, Czech Republic

[2] Masaryk Univ, Dept Clin Immunol & Allergol, Brno, Czech Republic

来源：

BLOOD | 2007年 / 109卷 / 06期

关键词：

D O I：

10.1182/blood-2006-07-037960

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The critical role of Bruton tyrosine kinase (Btk) in B cells has been documented by the block of B-cell development in X-linked agammaglobulinemia (XLA). Less is known about Btk function in myeloid cells. Several pieces of evidence indicate that Btk is a component of Toll-like receptor (TLR) signaling. We analyzed whether Btk deficiency in XLA is associated with an impaired dendritic cell (DC) compartment or defective TLR signaling. We analyzed the expression of TLRs 1 to 9 on myeloid DCs generated from XLA patients and evaluated their response to activation by specific TLR agonists. We show that XLA patients have normal numbers of circulating DCs. Btk-deficient DCs have no defect in response to stimulation of TLRs 1/2, 2/6, 3, 4, and 5 but display a profound impairment of IL-6 and TNF-alpha production in response to stimulation by TLR-8 cognate agonist, ssRNA. These findings may provide an explanation for the susceptibility to enteroviral infections in XLA patients.

引用

页码：2553 / 2556

页数：4

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