Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

被引：2662

作者：

Doehner, Hartmut ^{[1
]}

Estey, Elihu H. ^{[2
]}

Amadori, Sergio ^{[3
]}

Appelbaum, Frederick R. ^{[4
]}

Buechner, Thomas ^{[5
]}

Burnett, Alan K. ^{[6
]}

Dombret, Herve ^{[7
]}

Fenaux, Pierre ^{[8
]}

Grimwade, David ^{[9
]}

Larson, Richard A. ^{[10
,11
]}

Lo-Coco, Francesco ^{[12
,13
]}

Naoe, Tomoki ^{[14
]}

Niederwieser, Dietger ^{[15
]}

Ossenkoppele, Gert J. ^{[16
]}

Sanz, Miguel A. ^{[17
]}

Sierra, Jorge ^{[18
]}

Tallman, Martin S. ^{[19
]}

Loewenberg, Bob ^{[20
]}

Bloomfield, Clara D. ^{[21
]}

机构：

[1] Univ Ulm, Dept Internal Med 3, D-89081 Ulm, Germany

[2] Seattle Canc Ctr Alliance, Seattle, WA USA

[3] Tor Vergata Univ Hosp, Dept Hematol, Rome, Italy

[4] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA

[5] Univ Munster, Dept Hematol Oncol, Munster, Germany

[6] Cardiff Univ, Dept Haematol, Cardiff CF4 4XN, S Glam, Wales

[7] Hop St Louis, AP HP, Inst Univ Hematol, Paris, France

[8] Hop Avicenne, Serv Hematol Clin, F-93009 Bobigny, France

[9] Guys Kings & St Thomas Sch Med, Dept Med & Mol Genet, London, England

[10] Univ Chicago, Dept Med, Chicago, IL 60637 USA

[11] Univ Chicago, Canc Res Ctr, Chicago, IL 60637 USA

[12] Univ Tor Vergata, Dept Biopathol, Rome, Italy

[13] Ctr Europeo Ric Cervello, Santa Lucia Fdn, Rome, Italy

[14] Nagoya Univ Hosp, Dept Hematol, Showa Ku, Nagoya, Aichi, Japan

[15] Univ Leipzig, Dept Hematol Oncol & Hemostasis, Leipzig, Germany

[16] Vrije Univ Amsterdam, Med Ctr, Dept Haematol, Amsterdam, Netherlands

[17] Univ Hosp La Fe, Hematol & Bone Marrow Transplant Unit, Valencia, Spain

[18] Hosp Santa Creu & Sant Pau, Dept Clin Hematol, Barcelona, Spain

[19] Northwestern Univ, Div Hematol Oncol, Feinberg Sch Med, Chicago, IL 60611 USA

[20] Erasmus Univ, Med Ctr, Dept Hematol, Rotterdam, Netherlands

[21] Ohio State Univ, Ctr Comprehens Canc, Arthur G James Canc Hosp, Columbus, OH 43210 USA

来源：

BLOOD | 2010年 / 115卷 / 03期

关键词：

STEM-CELL TRANSPLANTATION; ACUTE MYELOGENOUS LEUKEMIA; COLONY-STIMULATING FACTOR; HIGH-DOSE CYTARABINE; BONE-MARROW-TRANSPLANTATION; RISK MYELODYSPLASTIC SYNDROME; TYROSINE KINASE INHIBITOR; MINIMAL-RESIDUAL-DISEASE; 1ST COMPLETE REMISSION; BALANCED CHROMOSOME-ABERRATIONS;

D O I：

10.1182/blood-2009-07-235358

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In 2003, an international working group last reported on recommendations for diagnosis, response assessment, and treatment outcomes in acute myeloid leukemia (AML). Since that time, considerable progress has been made in elucidating the molecular pathogenesis of the disease that has resulted in the identification of new diagnostic and prognostic markers. Furthermore, therapies are now being developed that target disease-associated molecular defects. Recent developments prompted an international expert panel to provide updated evidence- and expert opinion-based recommendations for the diagnosis and management of AML, that contain both minimal requirements for general practice as well as standards for clinical trials. A new standardized reporting system for correlation of cytogenetic and molecular genetic data with clinical data is proposed. (Blood. 2010; 115: 453-474)

引用

页码：453 / 474

页数：22

共 313 条

[71] Prevalence of HLA sensitization in female apheresis donors
Densmore, TL
Goodnough, LT
Ali, S
Dynis, M
Chaplin, H
[J]. TRANSFUSION, 1999, 39 (01) : 103 - 106
[72] Trisomy 13 is strongly associated with AML1/RUNX1 mutations and increased FLT3 expression in acute myeloid leukemia
Dicker, Frank
Haferlach, Claudia
Kern, Wolfgang
Haferlach, Torsten
Schnittger, Susanne
[J]. BLOOD, 2007, 110 (04) : 1308 - 1316
[73] Non-HLA genetics and predicting outcome in HSCT
Dickinson, A. M.
[J]. INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2008, 35 (4-5) : 375 - 380
[74] Molecular characterization of acute myeloid leukemia
Doehner, Konstanze
Doehner, Hartmut
[J]. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 (07): : 976 - 982
[75] Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics:: interaction with other gene mutations
Döhner, K
Schlenk, RF
Habdank, M
Scholl, C
Rücker, FG
Corbacioglu, A
Bullinger, L
Fröhling, S
Döhner, H
[J]. BLOOD, 2005, 106 (12) : 3740 - 3746
[76] A CONTROLLED-STUDY OF RECOMBINANT HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR IN ELDERLY PATIENTS AFTER TREATMENT FOR ACUTE MYELOGENOUS LEUKEMIA
DOMBRET, H
CHASTANG, C
FENAUX, P
REIFFERS, J
BORDESSOULE, D
BOUABDALLAH, R
MANDELLI, F
FERRANT, A
AUZANNEAU, G
TILLY, H
YVER, A
DEGOS, L
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (25) : 1678 - 1683
[77] Second transplant for acute and chronic leukemia relapsing after first HLA-identical sibling transplant
Eapen, M
Giralt, SA
Horowitz, MM
Klein, JP
Wagner, JE
Zhang, MJ
Tallman, MS
Marks, DI
Camitta, BM
Champlin, RE
Ringdén, O
Bredeson, CN
Martino, R
Gale, RP
Cairo, MS
Litzow, MR
deLima, M
[J]. BONE MARROW TRANSPLANTATION, 2004, 34 (08) : 721 - 727
[78] Identification of RPS14 as a 5q- syndrome gene by RNA interference screen
Ebert, Benjamin L.
Pretz, Jennifer
Bosco, Jocelyn
Chang, Cindy Y.
Tamayo, Pablo
Galili, Naomi
Raza, Azra
Root, David E.
Attar, Eyal
Ellis, Steven R.
Golub, Todd R.
[J]. NATURE, 2008, 451 (7176) : 335 - U7
[79] Comparison between four and eight cycles of intensive chemotherapy in adult acute myeloid leukemia:: a randomized trial of the Finnish Leukemia Group
Elonen, E
Almqvist, A
Hänninen, A
Jansson, SE
Järventie, G
Koistinen, P
Koivunen, E
Lahtinen, R
Lehtinen, M
Nousiainen, T
Pelliniemi, TT
Rajamäki, A
Remes, K
Timonen, T
Vilpo, J
Volin, L
Ruutu, T
[J]. LEUKEMIA, 1998, 12 (07) : 1041 - 1048
[80] Invasive fungal infections: a review of epidemiology and management options
Enoch, D. A.
Ludlam, H. A.
Brown, N. M.
[J]. JOURNAL OF MEDICAL MICROBIOLOGY, 2006, 55 (07) : 809 - 818

← 3 4 5 6 7 8 9 10 11 12 →