Endocytosis and signalling: A meeting with mathematics

被引：24

作者：

Birtwistle, Marc R. ^{[1
]}

Kholodenko, Boris N. ^{[1
,2
]}

机构：

[1] Univ Coll Dublin, Dublin 4, Ireland

[2] Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA

来源：

MOLECULAR ONCOLOGY | 2009年 / 3卷 / 04期

关键词：

Endocytosis; Mathematical modelling; Spatial gradients; Spatiotemporal dynamics; Signal transduction; EPIDERMAL-GROWTH-FACTOR; RECEPTOR-MEDIATED ENDOCYTOSIS; LOW-DENSITY-LIPOPROTEIN; CLATHRIN-COATED PITS; MAP KINASE; KINETIC-ANALYSIS; QUANTITATIVE-ANALYSIS; NEURONAL SURVIVAL; PLASMA-MEMBRANE; TUMOR SPHEROIDS;

D O I：

10.1016/j.molonc.2009.05.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although endocytosis has traditionally been understood as a signal attenuation mechanism, an emerging view considers endocytosis as an integral part of signal propagation and processing. on the short time scale, trafficking of endocytic vesicles contributes to signal propagation from the surface to distant targets, with bi-directional communication between signalling and trafficking. Mathematical modelling helps combine the mechanistic, molecular knowledge with rigorous analysis of the complex output dynamics of endocytosis in time and space. Simulations reveal novel roles for endocytosis, including the control of cell polarity, enhancing the spatial signal propagation, and controlling the signal magnitudes, kinetics, and synchronization with stimulus dynamics. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：308 / 320

页数：13

共 89 条

[1] Effect of antigen turnover rate and expression level on antibody penetration into tumor spheroids [J].