A Dα6 knockout strain of Drosophila melahogaster confers a high level of resistance to spinosad

被引：159

作者：

Perry, Trent ^{[1
]}

McKenzie, John A. ^{[1
]}

Batterham, Philip ^{[1
]}

机构：

[1] Univ Melbourne, Dept Genet, Ctr Environm Stress & Adaptat Res, Parkville, Vic 3052, Australia

来源：

INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2007年 / 37卷 / 02期

基金：

澳大利亚研究理事会;

关键词：

spinosad; nicotinic acetylcholine receptor; insecticide; CyO;

D O I：

10.1016/j.ibmb.2006.11.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A null mutation of the nicotinic acetylcholine receptor (nAChR) subunit Dab, in Drosophila melanogaster, confers 1181-fold resistance to a new and increasingly important biopesticide, spinosad. This study's molecular characterisation of a spinosad resistance mechanism identifies Do:6 as a major spinosad target in D. melanogaster. Although D. melanogaster is not a major field pest, target site resistances found in this species are often conserved in pest species. This, combined with the high degree of evolutionary conservation of nAChR subunits, suggests that mutations in Dab orthologues may underpin the spinosad resistance identified in several economically important field pests. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：184 / 188

页数：5

共 30 条

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