Silicon Nanoparticles as Hyperpolarized Magnetic Resonance Imaging Agents

被引：78

作者：

Aptekar, Jacob W. ^{[1
]}

Cassidy, Maja C. ^{[1
]}

Johnson, Alexander C. ^{[1
]}

Barton, Robert A. ^{[1
]}

Lee, Menyoung ^{[1
]}

Ogier, Alexander C. ^{[1
]}

Vo, Chinh ^{[1
]}

Anahtar, Melis N. ^{[2
]}

Ren, Yin ^{[2
]}

Bhatia, Sangeeta N. ^{[2
,3
]}

Ramanathan, Chandrasekhar ^{[4
]}

Cory, David G. ^{[4
]}

Hill, Alison L. ^{[5
]}

Mair, Ross W. ^{[5
]}

Rosen, Matthew S. ^{[1
,5
]}

Walsworth, Ronald L. ^{[1
,5
]}

Marcus, Charles M. ^{[1
]}

机构：

[1] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA

[2] MIT, Harvard MIT Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[3] Brigham & Womens Hosp, Div Med, Boston, MA 02115 USA

[4] MIT, Dept Nucl Sci & Engn, Cambridge, MA 02139 USA

[5] Harvard Smithsonian Ctr Astrophys, Cambridge, MA 02138 USA

来源：

ACS NANO | 2009年 / 3卷 / 12期

基金：

美国国家科学基金会;

关键词：

silicon nanoparticle; contrast agent; hyperpolarized; molecular imaging; functionalized nanoparticle; magnetic resonance imaging (MRI); nuclear magnetic resonance; nuclear spin relaxation; SUPERPARAMAGNETIC IRON-OXIDE; CONTRAST AGENTS; PARTICLES; DELIVERY; TUMORS;

D O I：

10.1021/nn900996p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Magnetic resonance imaging of hyperpolarized nuclei provides high image contrast with little or no background signal. To date, in vivo applications of prehyperpolarized materials have been limited by relatively short nuclear spin relaxation times. Here, we investigate silicon nanoparticles as a new type of hyperpolarized magnetic resonance imaging agent. Nuclear spin relaxation times for a variety of Si nanoparticles are found to be remarkably long, ranging from many minutes to hours at room temperature, allowing hyperpolarized nanoparticles to be transported, administered, and imaged on practical time scales. Additionally, we demonstrate that Si nanopartides can be surface functionalized using techniques common to other biologically targeted nanoparticle systems. These results suggest that Si nanoparticles can be used as a targetable, hyperpolarized magnetic resonance imaging agent with a large range of potential applications.

引用

页码：4003 / 4008

页数：6

共 34 条

[1] Nanocrystal targeting in vivo [J].