Interleukin-6-(IL-6) plasma levels in depression and schizophrenia: comparison between the acute state and after remission

被引:292
作者
Frommberger, UH
Bauer, J
Haselbauer, P
Fraulin, A
Riemann, D
Berger, M
机构
[1] Department of Psychiatry, University of Freiburg, D-79104 Freiburg
关键词
depression; schizophrenia; stress interleukin-6; psychoimmunology;
D O I
10.1007/BF02900219
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The concentration of cytokines such as Interleukin-6 (IL-6) has been reported to be elevated In depressed and schizophrenic patients and, in healthy persons, upon stress, Interleukin-6 plasma levels were determined in depressed (n = 12) and schizophrenic (n = 32) patients during the acute state of illness and after remission at approximately 8 weeks after admission and were compared with healthy controls: (n = 12). Patients were diagnosed according to DSM-III-R by the Structured Clinical Interview (SCID). Severity of illness was assessed for depression by the Montgomery Asberg Depression Rating Scale (MADRS) and for schizophrenia by the Brief Psychiatric Rating Scale (BPRS). Interleukin-6 plasma concentrations were elevated during the acute state either of depression or of schizophrenia if compared to controls. After remission, IL-6 concentrations in depressed and in schizophrenic patients had decreased and did not differ significantly from controls. Wen hypothesize that the elevated IL-6 levels during the acute state of depression or schizophrenia may reflect an unspecific stress response.
引用
收藏
页码:228 / 233
页数:6
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