A Magnetically Triggered Composite Membrane for On-Demand Drug Delivery

被引：284

作者：

Hoare, Todd ^{[2
]}

Santamaria, Jesus ^{[3
,4
]}

Goya, Gerardo F. ^{[4
]}

Irusta, Silvia ^{[3
,4
]}

Lin, Debora ^{[5
]}

Lau, Samantha ^{[5
]}

Padera, Robert ^{[6
]}

Langer, Robert ^{[5
]}

Kohane, Daniel S. ^{[1
]}

机构：

[1] Harvard Univ, Lab Biomat & Drug Delivery, Childrens Hosp Boston, Dept Anesthesiol,Div Crit Care Med,Med Sch, Boston, MA 02115 USA

[2] McMaster Univ, Dept Chem Engn, Hamilton, ON L8S 4L7, Canada

[3] Networking Biomed Res Ctr Bioengn Biomat & Nanome, Zaragoza 50018, Spain

[4] Univ Zaragoza, Inst Nanosci Aragon, E-50009 Zaragoza, Spain

[5] MIT, Dept Chem Engn, Cambridge, MA 02142 USA

[6] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

来源：

NANO LETTERS | 2009年 / 9卷 / 10期

基金：

加拿大自然科学与工程研究理事会;

关键词：

TEMPERATURE-SENSITIVE MEMBRANES; POLY N-ISOPROPYLACRYLAMIDE; PHASE-BEHAVIOR; RELEASE; HYDROGELS; PERMEATION; COPOLYMER; MICROGELS; POLYMERIZATION; NANOPARTICLES;

D O I：

10.1021/nl9018935

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanocomposite membranes based on thermosensitive poly(N-isopropylacrylamide)-based nanogels and magnetite nanoparticles have been designed to achieve "on-demand" drug delivery upon the application of an oscillating magnetic field. On-off release of sodium fluorescein over multiple magnetic cycles has been successfully demonstrated using prototype membrane-based devices. The total drug dose delivered was directly proportional to the duration of the "on" pulse. The membranes were noncytotoxic, were biocompatible, and retained their switchable flux properties after 45 days of subcutaneous Implantation.

引用

页码：3651 / 3657

页数：7

共 52 条

[1] Drug permeation through a temperature-sensitive poly(N-isopropylacrylamide) grafted poly(vinylidene fluoride) membrane [J].