Degradable polyelectrolyte capsules filled with oligonucleotide sequences

被引：187

作者：

Zelikin, Alexander N. ^{[1
]}

Li, Qi ^{[1
]}

Caruso, Frank ^{[1
]}

机构：

[1] Univ Melbourne, Dept Chem & Biomol Engn, Ctr Nanosci & Nanotechnol, Parkville, Vic 3010, Australia

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 46期

关键词：

degradable capsules; DNA; drug delivery; layer-by-layer technique; oligonucleotides;

D O I：

10.1002/anie.200602779

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

To cap it all: A polycation-free encapsulation method is used to obtain high concentrations of uncomplexed, short oligonucleotide chains confined within monodisperse, degradable microcapsules. Oligonucleotide loadings of > 104 chains per capsule are obtained, and more than 90% of the capsules are filled with DNA. These capsules also undergo degradation under reducing conditions (such as those that occur in cells), releasing the encapsulated DNA. (Figure Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7743 / 7745

页数：3

共 19 条

[1]

[Anonymous], ANGEW CHEM

[2] Nanoengineering of inorganic and hybrid hollow spheres by colloidal templating [J].