Testing times for the "amyloid cascade hypothesis"

被引：71

作者：

Hardy, J ^{[1
]}

机构：

[1] NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA

来源：

NEUROBIOLOGY OF AGING | 2002年 / 23卷 / 06期

关键词：

D O I：

10.1016/S0197-4580(02)00042-8

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

引用

页码：1073 / 1074

页数：2

共 11 条

[1] Linkage of plasma Aβ42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees [J].

Ertekin-Taner, N ;

Graff-Radford, N ;

Younkin, LH ;

Eckman, C ;

Baker, M ;

Adamson, J ;

Ronald, J ;

Blangero, J ;

Hutton, M ;

Younkin, SG .

SCIENCE, 2000, 290 (5500) :2303-+

[2] Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Aβ42 fibrils [J].

Götz, J ;

Chen, F ;

van Dorpe, J ;

Nitsch, RM .

SCIENCE, 2001, 293 (5534) :1491-1495

[3] Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease [J].

Janus, C ;

Pearson, J ;

McLaurin, J ;

Mathews, PM ;

Jiang, Y ;

Schmidt, SD ;

Chishti, MA ;

Horne, P ;

Heslin, D ;

French, J ;

Mount, HTJ ;

Nixon, RA ;

Mercken, M ;

Bergeron, C ;

Fraser, PE ;

St George-Hyslop, P ;

Westaway, D .

NATURE, 2000, 408 (6815) :979-982

[4] Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP [J].

Lewis, J ;

Dickson, DW ;

Lin, WL ;

Chisholm, L ;

Corral, A ;

Jones, G ;

Yen, SH ;

Sahara, N ;

Skipper, L ;

Yager, D ;

Eckman, C ;

Hardy, J ;

Hutton, M ;

McGowan, E .

SCIENCE, 2001, 293 (5534) :1487-1491

[5] Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease [J].

Morgan, D ;

Diamond, DM ;

Gottschall, PE ;

Ugen, KE ;

Dickey, C ;

Hardy, J ;

Duff, K ;

Jantzen, P ;

DiCarlo, G ;

Wilcock, D ;

Connor, K ;

Hatcher, J ;

Hope, C ;

Gordon, M ;

Arendash, GW .

NATURE, 2000, 408 (6815) :982-985

[6] Susceptibility locus for Alzheimer's disease on chromosome 10 [J].

Myers, A ;

Holmans, P ;

Marshall, H ;

Kwon, J ;

Meyer, D ;

Ramic, D ;

Shears, S ;

Booth, J ;

DeVrieze, FW ;

Crook, R ;

Hamshere, M ;

Abraham, R ;

Tunstall, N ;

Rice, F ;

Carty, S ;

Lillystone, S ;

Kehoe, P ;

Rudrasingham, V ;

Jones, L ;

Lovestone, S ;

Perez-Tur, J ;

Williams, J ;

Owen, MJ ;

Hardy, J ;

Goate, AM .

SCIENCE, 2000, 290 (5500) :2304-+

[7] The amyloid precursor protein locus and very-late-onset Alzheimer disease [J].

Olson, JM ;

Goddard, KAB ;

Dudek, DM .

AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 69 (04) :895-899

[8] Molecular mapping of Alzheimer-type dementia in Down's syndrome [J].

Prasher, VP ;

Farrer, MJ ;

Kessling, AM ;

Fisher, EMC ;

West, RJ ;

Barber, PC ;

Butler, AC .

ANNALS OF NEUROLOGY, 1998, 43 (03) :380-383

[9]

ROBINSON SR, 2002, IN PRESS NEUROBIOL D

[10] An honorable compromise regarding amyloid in Alzheimer disease [J].

Terry, RD .

ANNALS OF NEUROLOGY, 2001, 49 (05) :684-684

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