Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific marine hydroid Garveia annulata

被引：68

作者：

Pereira, Alban

Vottero, Eduardo

Roberge, Michel

Mauk, A. Grant

Andersen, Raymond J.

机构：

[1] Univ British Columbia, Dept Chem & EOS, Vancouver, BC V6T 1Z1, Canada

[2] Univ British Columbia, Life Sci Ctr, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z3, Canada

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 10期

关键词：

D O I：

10.1021/np060111x

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Crude extracts of the marine hydroid Garveia annulata show potent inhibition of indoleamine 2,3-dioxygenase (IDO). Fractionation of the extract led to the identification of the new polyketides annulin C (1), 2-hydroxygarveatin E (4), garveatin E (5), and garvin C (9). Annulins A (2), B (3), and C (1) were found to be submicromolar inhibitors of IDO.

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页码：1496 / 1499

页数：4

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