Fast, easy, solvent-free, microwave-promoted Michael addition of anilines to α,β-unsaturated alkenes:: synthesis of N-aryl functionalized β-amino esters and acids

被引：41

作者：

Amore, Kristen M. ^{[1
]}

Leadbeater, Nicholas E. ^{[1
]}

Miller, Tyson A. ^{[1
]}

Schmink, Jason R. ^{[1
]}

机构：

[1] Univ Connecticut, Dept Chem, Storrs, CT 06269 USA

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 48期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/j.tetlet.2006.09.114

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The rapid, simple, microwave-promoted synthesis of N-aryl functionalized beta-amino esters using Michael addition reactions is presented. Reactions are performed neat at 200 degrees C for 20 min and are catalyzed by acetic acid. The esters can be easily hydrolyzed to the corresponding N-aryl functionalized beta-amino acids. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：8583 / 8586

页数：4

共 33 条

[1] LiClO4 accelerated Michael addition of amines to α,β-unsaturated olefins under solvent-free conditions [J].