A History of Alcohol Dependence Increases the Incidence and Severity of Postoperative Cognitive Dysfunction in Cardiac Surgical Patients

被引：39

作者：

Hudetz, Judith A. ^{[1
,2
]}

Patterson, Kathleen M. ^{[2
,3
,4
,5
]}

Byrne, Alison J. ^{[2
]}

Iqbal, Zafar ^{[1
,2
]}

Gandhi, Sweeta D. ^{[1
,2
]}

Warltier, David C. ^{[1
,2
]}

Pagel, Paul S. ^{[1
,2
]}

机构：

[1] Med Coll Wisconsin, Dept Anesthesiol, Milwaukee, WI 53226 USA

[2] Clement J Zablocki Vet Adm Med Ctr, Milwaukee, WI 53295 USA

[3] Med Coll Wisconsin, Dept Psychiat, Milwaukee, WI 53226 USA

[4] Med Coll Wisconsin, Dept Behav Med, Milwaukee, WI 53226 USA

[5] Med Coll Wisconsin, Dept Neurol, Milwaukee, WI 53226 USA

来源：

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2009年 / 6卷 / 11期

关键词：

alcohol dependence; cardiac surgery; cardiopulmonary bypass; neurocognitive function; CORONARY-ARTERY-BYPASS; CARDIOPULMONARY BYPASS; INFLAMMATORY RESPONSE; EXECUTIVE FUNCTIONS; USE DISORDERS; FRONTAL-LOBE; SURGERY; DEFICITS; BRAIN; ABUSE;

D O I：

10.3390/ijerph6112725

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Postoperative cognitive dysfunction (POCD) commonly occurs after cardiac surgery. We tested the hypothesis that a history of alcohol dependence is associated with an increased incidence and severity of POCD in male patients undergoing cardiac surgery using cardiopulmonary bypass. Recent verbal and nonverbal memory and executive functions were assessed before and one week after surgery in patients with or without a history of alcohol dependence. Cognitive function was significantly reduced after cardiac surgery in patients with versus without a history of alcohol dependence. The results suggest that a history of alcohol dependence increases the incidence and severity of POCD after cardiac surgery.

引用

页码：2725 / 2739

页数：15

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