Vitamin D and respiratory health

被引：198

作者：

Hughes, D. A. ^{[1
]}

Norton, R. ^{[2
]}

机构：

[1] Inst Food Res, Norwich NR4 7UA, Norfolk, England

[2] Univ E Anglia, Sch Pharm, Norwich NR4 7TJ, Norfolk, England

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2009年 / 158卷 / 01期

关键词：

inflammation; immune function; lung; vitamin D; NF-KAPPA-B; 3RD NATIONAL-HEALTH; D-BINDING PROTEIN; 1,25-DIHYDROXYVITAMIN D-3; EPITHELIAL-CELLS; TRACT INFECTION; D DEFICIENCY; DIFFERENTIATION; INDUCTION; 25-HYDROXYVITAMIN-D;

D O I：

10.1111/j.1365-2249.2009.04001.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

P>Vitamin D is now known to be of physiological importance outside of bone health and calcium homeostasis, and there is mounting evidence that it plays a beneficial role in the prevention and/or treatment of a wide range of diseases. In this brief review the known effects of vitamin D on immune function are described in relation to respiratory health. Vitamin D appears capable of inhibiting pulmonary inflammatory responses while enhancing innate defence mechanisms against respiratory pathogens. Population-based studies showing an association between circulating vitamin D levels and lung function provide strong justification for randomized controlled clinical trials of vitamin D supplementation in patients with respiratory diseases to assess both efficacy and optimal dosage.

引用

收藏

页码：20 / 25

页数：6

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