Vitamin D and respiratory health

被引：198

作者：

Hughes, D. A. ^{[1
]}

Norton, R. ^{[2
]}

机构：

[1] Inst Food Res, Norwich NR4 7UA, Norfolk, England

[2] Univ E Anglia, Sch Pharm, Norwich NR4 7TJ, Norfolk, England

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2009年 / 158卷 / 01期

关键词：

inflammation; immune function; lung; vitamin D; NF-KAPPA-B; 3RD NATIONAL-HEALTH; D-BINDING PROTEIN; 1,25-DIHYDROXYVITAMIN D-3; EPITHELIAL-CELLS; TRACT INFECTION; D DEFICIENCY; DIFFERENTIATION; INDUCTION; 25-HYDROXYVITAMIN-D;

D O I：

10.1111/j.1365-2249.2009.04001.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

P>Vitamin D is now known to be of physiological importance outside of bone health and calcium homeostasis, and there is mounting evidence that it plays a beneficial role in the prevention and/or treatment of a wide range of diseases. In this brief review the known effects of vitamin D on immune function are described in relation to respiratory health. Vitamin D appears capable of inhibiting pulmonary inflammatory responses while enhancing innate defence mechanisms against respiratory pathogens. Population-based studies showing an association between circulating vitamin D levels and lung function provide strong justification for randomized controlled clinical trials of vitamin D supplementation in patients with respiratory diseases to assess both efficacy and optimal dosage.

引用

收藏

页码：20 / 25

页数：6

相关论文

共 50 条

[11] Treatment of vitamin D deficiency with UV light in patients with malabsorption syndromes: A case series [J].

Chandra, Prakash ;

Wolfenden, Linda L. ;

Ziegler, Thomas R. ;

Tian, Junqiang ;

Luo, Menghua ;

Stecenko, Arlene A. ;

Chen, Tai C. ;

Holick, Michael F. ;

Tangpricha, Vin .

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE, 2007, 23 (05) :179-185

[12] Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3 -: Involvement of NF-κB downregulation in transcriptional repression of the p40 gene [J].

D'Ambrosio, D ;

Cippitelli, M ;

Cocciolo, MG ;

Mazzeo, D ;

Di Lucia, P ;

Lang, R ;

Sinigaglia, F ;

Panina-Bordignon, P .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (01) :252-262

[13] Maternal vitamin D intake during pregnancy and early childhood wheezing [J].

Devereux, Graham ;

Litonjua, Augusto A. ;

Turner, Stephen W. ;

Craig, Leone C. A. ;

McNeill, Geraldine ;

Martindale, Sheelagh ;

Helms, Peter J. ;

Seaton, Anthony ;

Weiss, Scott T. .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2007, 85 (03) :853-859

[14] Vitamin D signaling is modulated on multiple levels in health and disease [J].

Ebert, R ;

Schütze, N ;

Adamski, J ;

Jakob, F .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2006, 248 (1-2) :149-159

[15]

Embry AF, 2000, ANN NEUROL, V48, P271, DOI 10.1002/1531-8249(200008)48:2<271::AID-ANA28>3.0.CO

[16]

2-O

[17] Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infection in the Third National Health and Nutrition Examination Survey [J].

Ginde, Adit A. ;

Mansbach, Jonathan M. ;

Camargo, Carlos A., Jr. .

ARCHIVES OF INTERNAL MEDICINE, 2009, 169 (04) :384-390

[18] Dendritic cell modulation by 1α,25 dihydroxyvitamin D3 and its analogs:: A vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo [J].

Griffin, MD ;

Lutz, W ;

Phan, VA ;

Bachman, LA ;

McKean, DJ ;

Kumar, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (12) :6800-6805

[19] Respiratory Epithelial Cells Convert Inactive Vitamin D to Its Active Form: Potential Effects on Host Defense [J].

Hansdottir, Sif ;

Monick, Martha M. ;

Hinde, Sara L. ;

Lovan, Nina ;

Look, Dwight C. ;

Hunninghake, Gary W. .

JOURNAL OF IMMUNOLOGY, 2008, 181 (10) :7090-7099

[20]

Holick MF, 2008, AM J CLIN NUTR, V87, p1080S

← 1 2 3 4 5 →