Plasticity during stroke recovery: from synapse to behaviour

被引：1339

作者：

Murphy, Timothy H. ^{[1
,2
,3
]}

Corbett, Dale ^{[4
]}

机构：

[1] Univ British Columbia, Dept Psychiat, Kinsmen Lab, Vancouver, BC V6T 1Z3, Canada

[2] Univ British Columbia, Brain Res Ctr, Vancouver, BC V6T 1Z3, Canada

[3] Univ British Columbia, Dept Cellular & Physiol Sci, Vancouver, BC V6T 1Z3, Canada

[4] Mem Univ Newfoundland, Fac Med, St John, NF A1B 3V6, Canada

来源：

NATURE REVIEWS NEUROSCIENCE | 2009年 / 10卷 / 12期

基金：

加拿大健康研究院;

关键词：

FOCAL CEREBRAL-ISCHEMIA; EXPERIENCE-DEPENDENT PLASTICITY; CONSTRAINT-INDUCED MOVEMENT; FUNCTIONAL MOTOR RECOVERY; LONG-TERM POTENTIATION; GROWTH-ASSOCIATED GENE; SILENT BRAIN INFARCTS; IN-VIVO REVEALS; SPINAL-CORD; NEUROTROPHIC FACTOR;

D O I：

10.1038/nrn2735

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Reductions in blood flow to the brain of sufficient duration and extent lead to stroke, which results in damage to neuronal networks and the impairment of sensation, movement or cognition. Evidence from animal models suggests that a time-limited window of neuroplasticity opens following a stroke, during which the greatest gains in recovery occur. Plasticity mechanisms include activity-dependent rewiring and synapse strengthening. The challenge for improving stroke recovery is to understand how to optimally engage and modify surviving neuronal networks, to provide new response strategies that compensate for tissue lost to injury.

引用

页码：861 / 872

页数：12

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