Diastereoselective Henry reactions of N,N-dibenzyl α-amino aldehydes with nitromethane catalyzed by enantiopure guanidines

被引：50

作者：

Ma, DW

Pan, QB

Han, FS

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

[2] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 51期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/S0040-4039(02)02332-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several enantiopure guanidines are studied as the catalysts of Henry reactions of N,N-dibenzyl alpha-amino aldehydes with nitromethane. Good diastereoselectivity is observed in the reactions of L-valine or L-isoleucine derived aldehydes catalyzed by a (R)-1-(1-naphthyl)ethylamine derived guanidine. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：9401 / 9403

页数：3

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