Mutagenic activity of a fluorinated analog of the beta-adrenoceptor ligand carazolol in the Ames test

被引：14

作者：

Doze, P ^{[1
]}

Elsinga, PH ^{[1
]}

de Vries, EFJ ^{[1
]}

Van Waarde, A ^{[1
]}

Vaalburg, W ^{[1
]}

机构：

[1] Univ Groningen Hosp, PET Ctr, NL-9700 RB Groningen, Netherlands

来源：

NUCLEAR MEDICINE AND BIOLOGY | 2000年 / 27卷 / 03期

关键词：

PET; mutagenicity; beta-adrenoceptors; fluorine introduction;

D O I：

10.1016/S0969-8051(00)00087-1

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

S-1'[F-18]-Fluorocarazolol (FCAR) is a fluorinated analog of the nonmutagenic beta-blocker carazolol (CAR). Tn former studies FCAR proved to be suitable for quantification of beta-adrenoceptors in vivo with positron emission tomography (PET). We report here that FCAR displays no acute toxicity in either rats or mice. However, FCAR induces a strong dose-related increase in the number of revertants in the Ames test. We conclude that FCAR yields mutagenic activity as measured by the Ames test. NUCL MED BIOL 27;3:315-319, 2000. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：315 / 319

页数：5

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