High-resolution x-ray CT screening of mutant mouse models

被引：13

作者：

Paulus, MJ ^{[1
]}

Gleason, SS ^{[1
]}

Sari-Sarraf, H ^{[1
]}

Johnson, DK ^{[1
]}

Foltz, CJ ^{[1
]}

Austin, DW ^{[1
]}

Easterly, ME ^{[1
]}

Michaud, EJ ^{[1
]}

Dhar, MS ^{[1
]}

Hunsicker, PR ^{[1
]}

Wall, JW ^{[1
]}

Schell, M ^{[1
]}

机构：

[1] Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA

来源：

OPTICAL DIAGNOSTICS OF LIVING CELLS III | 2000年 / 3921卷

关键词：

small animal imaging; x-ray; computed tomography;

D O I：

10.1117/12.384221

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A dedicated small animal x-ray computed tomography system has been developed to screen mutagenized mice for anatomical phenotypes. The key components of the data acquisition instrumentation are described along with the system performance parameters. Image reconstruction, visualization and segmentation software algorithms are described. Two contrast media regimens are described and representative studies of mice with adipose, soft and skeletal tissue abnormalities are presented.

引用

页码：270 / 279

页数：10

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