Competitive inhibition of swine kidney copper amine oxidase by drugs: Amiloride, clonidine, and gabexate mesylate

被引：22

作者：

Federico, R

Angelini, R

Ercolini, L

Venturini, G

Mattevi, A

Ascenzi, P

机构：

[1] UNIV ROME 3, DEPT BIOL, I-00146 ROME, ITALY

[2] UNIV PAVIA, DEPT GENET & MICROBIOL, I-27100 PAVIA, ITALY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 240卷 / 01期

关键词：

D O I：

10.1006/bbrc.1997.7630

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Competitive inhibition of swine kidney copper amine oxidase by diuretic, antihypertensive, and anticoagulant drugs, amiloride, clonidine, and gabexate mesylate, respectively, is reported. The affinity of these compounds for swine kidney copper amine oxidase is similar to that observed for inhibitor binding to nitric oxide synthase and trypsin-like serine proteinases. This finding suggests that amiloride, clonidine, and gabexate mesylate should be administrated under careful control, since enzyme cross-inhibition may occur also in vivo. (C) 1997 Academic Press.

引用

页码：150 / 152

页数：3

共 19 条

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