Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440

被引：1054

作者：

Nelson, KE

Weinel, C

Paulsen, IT

Dodson, RJ

Hilbert, H

dos Santos, VAPM

Fouts, DE

Gill, SR

Pop, M

Holmes, M

Brinkac, L

Beanan, M

DeBoy, RT

Daugherty, S

Kolonay, J

Madupu, R

Nelson, W

White, O

Peterson, J

Khouri, H

Hance, I

Lee, PC

Holtzapple, E

Scanlan, D

Tran, K

Moazzez, A

Utterback, T

Rizzo, M

Lee, K

Kosack, D

Moestl, D

Wedler, H

Lauber, J

Stjepandic, D

Hoheisel, J

Straetz, M

Heim, S

Kiewitz, C

Eisen, J

Timmis, KN

Düsterhöft, A

Tümmler, B

Fraser, CM

机构：

[1] Inst Genom Res, Rockville, MD 20850 USA

[2] Hannover Med Sch, Klin Forschergrp, Hannover, Germany

[3] Qiagen GmbH, Hilden, Germany

[4] Gesell Biotechnol Forsch mbH, D-3300 Braunschweig, Germany

[5] Deutsch Krebsforschungszentrum, D-6900 Heidelberg, Germany

来源：

ENVIRONMENTAL MICROBIOLOGY | 2002年 / 4卷 / 12期

关键词：

D O I：

10.1046/j.1462-2920.2002.00366.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Pseudomonas putida is a metabolically versatile saprophytic soil bacterium that has been certified as a biosafety host for the cloning of foreign genes. The bacterium also has considerable potential for biotechnological applications. Sequence analysis of the 6.18 Mb genome of strain KT2440 reveals diverse transport and metabolic systems. Although there is a high level of genome conservation with the pathogenic Pseudomonad Pseudomonas aeruginosa (85% of the predicted coding regions are shared), key virulence factors including exotoxin A and type III secretion systems are absent. Analysis of the genome gives insight into the non-pathogenic nature of P. putida and points to potential new applications in agriculture, biocatalysis, bioremediation and bioplastic production.

引用

页码：799 / 808

页数：10

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[11] Bioaugmentation of soils by increasing microbial richness: missing links [J].