Tissue remodelling through branching morphogenesis

被引：144

作者：

Affolter, Markus ^{[1
]}

Zeller, Rolf ^{[2
]}

Caussinus, Emmanuel ^{[1
]}

机构：

[1] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland

[2] Univ Basel, Dept Biomed, CH-4058 Basel, Switzerland

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2009年 / 10卷 / 12期

关键词：

ESTROGEN-RECEPTOR-ALPHA; MAMMARY-GLAND DEVELOPMENT; ENDOTHELIAL GROWTH-FACTOR; TRACHEAL CELL-MIGRATION; MOLECULAR-MECHANISMS; METANEPHRIC KIDNEY; FEEDBACK LOOP; KEY STAGES; END BUD; DROSOPHILA;

D O I：

10.1038/nrm2797

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Branched structures are evident at all levels of organization in living organisms. Many organs, such as the vascular system, lung, kidney and mammary gland, are heavily branched. In each of these cases, equally fascinating questions have been put forward, including those that address the cellular and molecular mechanisms that regulate the branching process itself, such as where the branches are initiated and how they extend and grow in the right direction. Recent experiments suggest that cell competition and cell rearrangements might be conserved key features in branch formation and might be controlled by local cell signalling.

引用

页码：831 / 842

页数：12

共 113 条

[21] Feedback control of mammalian hedgehog signaling by the hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung [J].