Aging in the hippocampus: Interrelated actions of neurotrophins and glucocorticoids

被引：29

作者：

McLay, RN

Freeman, SM

Harlan, RE

Ide, CF

Kastin, AJ

Zadina, JE

机构：

[1] TULANE UNIV, SCH MED, DEPT PATHOL, NEW ORLEANS, LA 70112 USA

[2] TULANE UNIV, SCH MED, PROGRAM NEUROSCI, NEW ORLEANS, LA 70112 USA

[3] TULANE UNIV, SCH MED, DEPT ANAT, NEW ORLEANS, LA 70112 USA

[4] TULANE UNIV, DEPT CELL & MOL BIOL, NEW ORLEANS, LA 70118 USA

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 1997年 / 21卷 / 05期

关键词：

Alzheimer's Disease; adrenalectomy; aging; brain-derived neurotrophic factor; calcium; corticosteroids; feedback; growth factors; hippocampus; hypothalamic-pituitary-adrenal axis; glucocorticoids; learning; memory; neurotrophins; nerve growth factors; pyramidal neurons; senility; steroids; stress;

D O I：

10.1016/S0149-7634(96)00046-2

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Over the past two decades, evidence has been accumulating that diffusible molecules, such as growth factors and steroid hormones, play an important part in neural senescence, particularly in the hippocampus. There is also evidence that these molecules do not act as independent signals, but show interrelated regulation and cooperative control over the aging process. Here, we review some of the changes that occur in the hippocampus with age, and the influence of two classes of signaling substances: glucocorticoids and neurotrophins. We also examine the interactions between these substances and how this could influence the aging process. Published by Elsevier Science Ltd.

引用

页码：615 / 629

页数：15

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