A Typhus Group-Specific Protease Defies Reductive Evolution in Rickettsiae

被引：12

作者：

Ammerman, Nicole C. ^{[1
]}

Gillespie, Joseph J. ^{[1
,2
]}

Neuwald, Andrew F. ^{[3
]}

Sobral, Bruno W. ^{[2
]}

Azad, Abdu F. ^{[1
]}

机构：

[1] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA

[2] Virginia Tech, Virginia Bioinformat Inst, Blacksburg, VA 24061 USA

[3] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA

来源：

JOURNAL OF BACTERIOLOGY | 2009年 / 191卷 / 24期

关键词：

PROLYL OLIGOPEPTIDASE; PSI-BLAST; PEPTIDASE; PROTEINASE; MECHANISMS; PREDICTION; DIVERSITY; CATALYSIS;

D O I：

10.1128/JB.01077-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Phylogenomics reveals extreme gene loss in typhus group (TG) rickettsiae relative to the levels for other rickettsial lineages. We report here a curious protease-encoding gene (ppcE) that is conserved only in TG rickettsiae. As a possible determinant of host pathogenicity, ppcE warrants consideration in the development of therapeutics against epidemic and murine typhus.

引用

页码：7609 / 7613

页数：5

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