Uncoupling ribosome biogenesis regulation from RNA polymerase I activity during herpes simplex virus type 1 infection

被引：20

作者：

Belin, Stephane ^{[1
,2
]}

Kindbeiter, Karine ^{[3
]}

Hacot, Sabine ^{[1
,2
]}

Albaret, Marie Alexandra ^{[1
,2
,3
]}

Roca-Martinez, Jean-Xavier ^{[1
,2
,3
]}

Therizols, Gabriel ^{[1
,2
]}

Grosso, Olivier ^{[4
]}

Diaz, Jean-Jacques ^{[1
,2
]}

机构：

[1] Univ Lyon, Ctr Leon Berard, Ctr Genet Mol & Cellulaire, F-69373 Lyon, France

[2] Univ Lyon, CNRS, F-69003 Lyon, France

[3] Idealp Pharma, F-69603 Villeurbanne, France

[4] Univ Lyon, INPL, F-69622 Villeurbanne, France

来源：

RNA | 2010年 / 16卷 / 01期

关键词：

HSV-1; pre-rRNA; ribosome; RNA polymerase I; PROTEIN-SYNTHESIS; NUCLEAR EXPORT; PHOSPHORYLATION; CELLS; P53; INHIBITION; L11; IDENTIFICATION; TRANSLATION; EXPRESSION;

D O I：

10.1261/rna.1935610

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ribosome is the central effector of protein synthesis, and its synthesis is intimately coordinated with that of proteins. At present, the most documented way to modulate ribosome biogenesis involves control of rDNA transcription by RNA polymerase I (RNA Pol I). Here we show that after infection of human cells with herpes simplex virus type 1 (HSV-1) the rate of ribosome biogenesis is modulated independently of RNA Pol I activity by a dramatic change in the rRNA maturation pathway. This process permits control of the ribosome biogenesis rate, giving the possibility of escaping ribosomal stress and eventually allowing assembly of specialized kinds of ribosomes.

引用

页码：131 / 140

页数：10

共 40 条

[1] Stress signals utilize multiple pathways to stabilize p53 [J].