Systemic autoimmune disorders in celiac disease

被引:61
作者
Fasano, Alessio
机构
[1] Univ Maryland, Sch Med, Mucosal Biol Res Ctr, Baltimore, MD 21201 USA
[2] Univ Maryland, Sch Med, Ctr Celiac Res, Baltimore, MD 21201 USA
[3] Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA
关键词
autoimmunity; innate immunity; intestinal permeability; tight junctions; Toll receptors;
D O I
10.1097/01.mog.0000245543.72537.9e
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Purpose of review Celiac disease is an immune-mediated disorder clinically characterized by a multitude of symptoms and complications. The comorbidity between celiac disease and other autoimmune disorders has been clearly established. Recent findings Two main theories have been postulated to explain this comorbidlty: (1) linkage disequilibrium between the genes responsible for celiac disease and those responsible for the coexpressed autoimmune diseases or (2) untreated celiac disease leading to the onset of other autoimmune diseases. This article reviews the current literature supporting either,,theory and places the current knowledge in the field within the context of the most recent data on the pathogenesis of celiac disease. Summary The current literature did not clearly establish which of the two theories explain the comorbidity between celiac disease and other autoimmune disorders. There is, however, growing evidence that the loss of the intestinal barrier function typical of celiac disease could be responsible of the onset of other autoimmune disease. This concept implies that the autoimmune response can be theoretically stopped and perhaps reversed if the interplay between autoimmune predisposing genes and trigger(s) is prevented or eliminated by a prompt diagnosis and treatment.
引用
收藏
页码:674 / 679
页数:6
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