TNF-α in promotion and progression of cancer

被引：758

作者：

Balkwill, Frances ^{[1
]}

机构：

[1] Barts & London Queen Marys Sch Med & Dent, Ctr Translat Oncol, Inst Canc, John Vane Sci Ctr, London EC1M 6BQ, England

来源：

CANCER AND METASTASIS REVIEWS | 2006年 / 25卷 / 03期

基金：

英国医学研究理事会;

关键词：

TNF-alpha; inflammation; cytokine; chemokine;

D O I：

10.1007/s10555-006-9005-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumour necrosis factor alpha is a member of the TNF/TNFR cytokine superfamily. In common with other family members, TNF-alpha is involved in maintenance and homeostasis of the immune system, inflammation and host defence. However, there is a 'dark side' to this powerful cytokine; it is now clear that, especially in middle and old age, TNF-alpha is involved in pathological processes such as chronic inflammation, autoimmunity and, in apparent contradiction to its name, malignant disease. This article will discuss the involvement of TNF-alpha in the inflammatory network that contributes to all stages of the malignant process, and consider the possibility that TNF-alpha may be a target for cancer therapy.

引用

页码：409 / 416

页数：8