Quest for fire - Seeking the source of pathogenic oxygen radicals in atherosclerosis

被引:20
作者
Schultz, D
Harrison, DG
机构
[1] Emory Univ, Sch Med, Div Cardiol, Atlanta, GA 30322 USA
[2] Emory Univ, Sch Med, Vasc Biol Ctr, Atlanta, GA 30322 USA
[3] Atlanta VA Med Ctr, Atlanta, GA USA
关键词
editorials; reactive oxygen species; superoxide; atherosclerosis; NADPH oxidases;
D O I
10.1161/01.ATV.20.6.1412
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
There is an accumulating body evidence that atherosclerosis is either caused by or accompanied by oxidative events in the vessel wall. These oxidative events have been implicated in proatherogenic modification of proteins, alteration of gene expression, promotion of inflammation, remodeling of vessels, and perturbations of vascular tone. This body of literature has led to a dogma that oxidation is a prerequisite for the atherosclerotic process. In particular, oxidation of lipoproteins by activated macrophages in the subintimal space has been postulated to be an important early step in the atherosclerotic process.
引用
收藏
页码:1412 / 1413
页数:2
相关论文
共 9 条
[1]   HUMAN NEUTROPHIL CYTOCHROME-B LIGHT CHAIN (P22-PHOX) - GENE STRUCTURE, CHROMOSOMAL LOCATION, AND MUTATIONS IN CYTOCHROME-NEGATIVE AUTOSOMAL RECESSIVE CHRONIC GRANULOMATOUS-DISEASE [J].
DINAUER, MC ;
PIERCE, EA ;
BRUNS, GAP ;
CURNUTTE, JT ;
ORKIN, SH .
JOURNAL OF CLINICAL INVESTIGATION, 1990, 86 (05) :1729-1737
[2]   CYTOCHROME B-558 ALPHA-SUBUNIT CLONING AND EXPRESSION IN RAT AORTIC SMOOTH-MUSCLE CELLS [J].
FUKUI, T ;
LASSEGUE, B ;
KAI, H ;
ALEXANDER, RW ;
GRIENDLING, KK .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1995, 1231 (03) :215-219
[3]   Expression of phagocyte NADPH oxidase components in human endothelial cells [J].
Jones, SA ;
ODonnell, VB ;
Wood, JD ;
Broughton, JP ;
Hughes, EJ ;
Jones, OTG .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1996, 271 (04) :H1626-H1634
[4]   Impaired superoxide production due to a deficiency in phagocyte NADPH oxidase fails to inhibit atherosclerosis in mice [J].
Kirk, EA ;
Dinauer, MC ;
Rosen, H ;
Chait, A ;
Heinecke, JW ;
LeBoeuf, RC .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (06) :1529-1535
[5]   Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis [J].
Miller, FJ ;
Gutterman, DD ;
Rios, CD ;
Heistad, DD ;
Davidson, BL .
CIRCULATION RESEARCH, 1998, 82 (12) :1298-1305
[6]   Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation - Contribution to alterations of vasomotor tone [J].
Rajagopalan, S ;
Kurz, S ;
Munzel, T ;
Tarpey, M ;
Freeman, BA ;
Griendling, KK ;
Harrison, DG .
JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (08) :1916-1923
[7]   CYTOCHROME-B558 - THE FLAVIN-BINDING COMPONENT OF THE PHAGOCYTE NADPH OXIDASE [J].
ROTROSEN, D ;
YEUNG, CL ;
LETO, TL ;
MALECH, HL ;
KWONG, CH .
SCIENCE, 1992, 256 (5062) :1459-1462
[8]  
TILLMAN C, 1999, J CLIN INVEST, V103, P1597
[9]  
YOUNGAH S, 1999, NATURE, V401, P79