Molecular imaging in drug discovery and development

被引：623

作者：

Rudin, M

Weissleder, R ^{[1
]}

机构：

[1] Novartis Inst Biomed Res, CH-4002 Basel, Switzerland

[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Mol Imaging Res, Charlestown, MA 02129 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2003年 / 2卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrd1007

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Imaging sciences have grown exponentially during the past three decades, and many techniques, such as magnetic resonance imaging, nuclear tomographic imaging and X-ray computed tomography, have become indispensable in clinical use. Advances in imaging technologies and imaging probes for humans and for small animals are now extending the applications of imaging further into drug discovery and development, and have the potential to considerably accelerate the process. This review summarizes some of the recent developments in conventional and molecular imaging, and highlights their impact on drug discovery.

引用

页码：123 / 131

页数：9

共 83 条

[71]

TJUVAJEV JG, 1995, CANCER RES, V55, P6126

[72] Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy [J].