Procyanidins Extracted from the Lotus Seedpod Ameliorate Scopolamine-induced Memory Impairment in Mice

被引：26

作者：

Xu, Jiqu ^{[1
,2
]}

Rong, Shuang ^{[1
,2
]}

Xie, Bijun ^{[3
]}

Sun, Zhida ^{[3
]}

Zhang, Li ^{[4
]}

Wu, Hailei ^{[1
,2
]}

Yao, Ping ^{[1
,2
]}

Zhang, Yunjian ^{[4
]}

Liu, Liegang ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Food Hyg & Nutr, Wuhan 430030, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, MOE Key Lab Environm & Hlth, Wuhan 430030, Peoples R China

[3] Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Peoples R China

[4] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Neurol, Wuhan 430022, Peoples R China

来源：

PHYTOTHERAPY RESEARCH | 2009年 / 23卷 / 12期

关键词：

procyanidins; scopolamine; memory; Morris water maze; step-down avoidance test; AChE activity; CENTRAL-NERVOUS-SYSTEM; CHOLINERGIC HYPOTHESIS; ACETYLCHOLINE-RELEASE; WATER-MAZE; BRAIN; ANTIOXIDANTS; TARGETS; SAFETY; AGE;

D O I：

10.1002/ptr.2837

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The major purpose of this study was to determine the effect of procyanidins extracted from the lotus seedpod (LSPC) on the learning and memory impairments induced by scopolamine (1 mg/kg, i.p.) in mice. The capacities of memory and learning were evaluated by the Morris water maze and the step-down avoidance test. LSPC (50, 100, 150 mg/kg BW, p.o.) significantly reversed scopolamine-induced learning and memory impairments in the Morris water maze test, as evaluated by shortened escape latency and swimming distance. In the step-down avoidance test, LSPC (50, 100, 150 mg/kg BW, p.o.) treatment significantly reduced the number of errors and shortened latency compared with that of scopolamine. In addition, LSPC was also found to inhibit acetyl cholinesterase (ACNE) activity. These results of this study suggest that LSPC may play a useful role in the treatment of cognitive impairment caused by AD and aging. Copyright (C) 2009 John Wiley & Sons, Ltd.

引用

页码：1742 / 1747

页数：6

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