A novel phenol-forming reaction for preparation of benzene, furan, and thiophene analogs of CC-1065/duocarmycin pharmacophores

被引：77

作者：

Muratake, H

Hayakawa, A

Natsume, M

机构：

[1] Research Foundation Itsuu Laboratory, Tokyo 158, 2-28-10 Tamagawa, Setagaya-ku

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 43期

关键词：

D O I：

10.1016/S0040-4039(97)01786-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalyzed intramolecular coupling reaction between methyl ketones and triflates was developed for preparation of phenol derivatives 13, 14, and 15 from 10, 11, and 12 in high yields. Potent antitumor substances 35, 36, and 37 were prepared from 13, 14, and 15. (C) 1997 Elsevier Science Ltd.

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页码：7577 / 7580

页数：4

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