The bacterial replication initiator DnaA.: DnaA and oriC, the bacterial mode to initiate DNA replication

被引：179

作者：

Messer, W ^{[1
]}

机构：

[1] Max Planck Inst Mol Genet, D-14195 Berlin, Germany

来源：

FEMS MICROBIOLOGY REVIEWS | 2002年 / 26卷 / 04期

关键词：

protein domain; DnaB helicase; ATP-binding DnaA box; plasmid;

D O I：

10.1111/j.1574-6976.2002.tb00620.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The initiation of replication is the central event in the bacterial cell cycle. Cells control the rate of DNA synthesis by modulating the frequency with which new chains are initiated, like all macromolecular synthesis. The end of the replication cycle provides a checkpoint that must be executed for cell division to occur. This review summarizes recent insight into the biochemistry, genetics and control of the initiation of replication in bacteria, and the central role of the initiator protein DnaA. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：355 / 374

页数：20

共 234 条

[131] ACTIVATION OF DISTANT REPLICATION ORIGINS INVIVO BY DNA LOOPING AS REVEALED BY A NOVEL MUTANT FORM OF AN INITIATOR PROTEIN DEFECTIVE IN COOPERATIVITY AT A DISTANCE [J].