ECaC:: the gatekeeper of transepithelial Ca2+ transport

被引：54

作者：

Hoenderop, JGJ

Nilius, B

Bindels, RJM

机构：

[1] Univ Nijmegen, Ctr Med, Dept Cell Physiol, Nijmegon Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands

[2] Catholic Univ Louvain, Dept Physiol, B-3000 Louvain, Belgium

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS | 2002年 / 1600卷 / 1-2期

关键词：

calcium channel; vitamin D; calcium absorption; kidney; small intestine; PTH; TRPV5; TRPV6; ECaC1; ECaC2;

D O I：

10.1016/S1570-9639(02)00438-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The epithelial Ca2+ channels (ECaCs) are primarily expressed in Ca2+ transporting epithelia and represent a new family of Ca2+ channels that belong to the superfamily of transient receptor potential (TRP) channels. Two members, namely ECaC1 and ECaC2, have been identified from kidney and intestine, respectively. These channels are the prime target for hormonal control of active Ca2+ flux from the urine space or intestinal lumen to the blood compartment. This review covers the distinctive properties of these highly Ca2+-selective channels and highlights the implications for our understanding of the process of transepithelial Ca2+ transport. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：6 / 11

页数：6

共 48 条

[41] Pore properties and ionic block of the rabbit epithelial calcium channel expressed in HEK 293 cells [J].