MRMaid-DB: A Repository of Published SRM Transitions

被引：16

作者：

Cham , Jennifer A. ^{[1
]}

Bianco, Luca ^{[1
]}

Barton, Chris ^{[2
]}

Bessant, Conrad ^{[1
]}

机构：

[1] Cranfield Univ, Bioinformat Grp, Cranfield MK43 0AL, Beds, England

[2] Quotient Biores Ltd, Fordham CB7 5WW, Cambs, England

来源：

JOURNAL OF PROTEOME RESEARCH | 2010年 / 9卷 / 01期

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

Biomart; database; multiple reaction monitoring (MRM); selected reaction monitoring (SRM); Web-based; CHROMATOGRAPHY/TANDEM MASS-SPECTROMETRY; REACTION MONITORING ASSAYS; PLASMA-PROTEINS; QUANTIFICATION; QUANTITATION; DATABASES; SERUM;

D O I：

10.1021/pr900713u

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Selected reaction monitoring (SRM) is a technique that applies tandem mass spectrometry to quantify specific proteins of biological interest. The key to SRM is finding the best peptide-to-product ion transitions to monitor. The MRMaid database (MRMaid-DB) is a new online database for capturing SRM transitions from published research papers to save practitioners time when searching for transitions that have been previously validated. It contains all the information needed to reproduce the transitions, such as information on the sample matrix HPLC, and MS instrumentation used, and also includes details of the manuscript of origin. Transitions are submitted using simple Web-based data entry forms, meaning researchers have a simple way to increase access to their transitions, and in turn, may increase the citations for their research papers. MRMaid-DB is free to use, via the Web at www.mrmaid-db.info.

引用

页码：620 / 625

页数：6

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