A stress response pathway involving sirtuins, forkheads and 14-3-3 proteins

被引：52

作者：

Berdichevsky, Ala ^{[1
]}

Guarente, Leonard ^{[1
]}

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

CELL CYCLE | 2006年 / 5卷 / 22期

关键词：

aging; SIR-2.1; 14-3-3; stress; DAF-16;

D O I：

10.4161/cc.5.22.3513

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A conserved sir2 deacetylase gene can determine longevity of yeast, flies and worms. Recently we have reported a molecular mechanism of action of the C. elegans homologue sir-2.1. Our study revealed a novel stress-dependent pathway for lifespan determination in which SIR-2.1 binds to 14-3-3 proteins and a forkhead transcription factor DAF-16 to activate transcription of DAF-16 target genes. DAF-16 has long been known as a central protein in the regulation of lifespan that interfaces with multiple pathways. Recent studies by us and other laboratories suggest that DAF-16 requires co-factors for full activity. In this prospective we review recent literature highlighting the role of SIR-2.1, 14-3-3 and other DAF-16 co-factors in DAF-16 activation.

引用

收藏

页码：2588 / 2591

页数：4

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