Differential expression of two distinct vesicular glutamate transporters in the rat retina

被引：35

作者：

Mimura, Y

Mogi, K

Kawano, M

Fukui, Y

Takeda, J

Nogami, H

Hisano, S ^{[1
]}

机构：

[1] Univ Tsukuba, Inst Basic Med Sci, Neuroendocrinol Lab, Tsukuba, Ibaraki 3058575, Japan

[2] Univ Tokushima, Sch Med, Dept Anat, Tokushima 7708503, Japan

[3] Gunma Univ, Inst Mol & Cellular Regulat, Dept Cell Biol, Gunma 3718512, Japan

来源：

NEUROREPORT | 2002年 / 13卷 / 15期

关键词：

BNPI; DNPI; rat; retina; vesicular glutamate transporter;

D O I：

10.1097/00001756-200210280-00019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Expression and cellular localization of vesicular glutamate transporters (BNPI and DNPI) were studied in the rat retina. RT-PCR showed expression of both transporter mRNAs. In situ hybridization demonstrated BNPI mRNA signals in the inner segments of photoreceptors and the inner nuclear layer, whereas DNPI mRNA signals were confined to the ganglion cell layer. Punctate BNPI immunoreactivity was localized in the inner and outer plexiform layers, and weak DNPI immunoreactivity was detectable only in some cells and fibers of the ganglion cell layer. The present study suggests that BNPI exists in photoreceptors and bipolar cells, while DNPI is present in ganglion cells, as specific systems in distinct glutamatergic neurons of the retina.

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页码：1925 / 1928

页数：4

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