Diagnosis of Epstein-Barr virus-associated diseases

被引：33

作者：

Tsuchiya, S ^{[1
]}

机构：

[1] Tohoku Univ, Dept Pediat Oncol, Res Inst Dev Aging & Canc, Aoba Ku, Sendai, Miyagi 9808575, Japan

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2002年 / 44卷 / 03期

关键词：

Epstein-Barr virus-associated disease; serology; immunochemistry; molecular diagnosis;

D O I：

10.1016/S1040-8428(02)00114-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epstein-Barr virus (EBV) is a common DNA virus distributed worldwide. Usually the initial infection involves the upper respiratory tract without any problems and almost the entire population more than 25 years old test positive for anti-EBV antibodies. However, EBV often causes not only acute lytic infection but also chronic active infection with B cells and even T cells. In addition the EBV genome has been detected in tumors of hematopoietic or epithelial cell origin such as Burkitt's lymphomas, Hodgkin's disease, NK/T cell lymphomas, nasopharyngeal carcinomas (NPCs) and gastric adenocarcinomas. It is clearly important to make a correct diagnosis for EBV associated diseases and monitor the EBV load in individual patients for an appropriate therapy. In this paper recent advances in serological, immunological and molecular approaches for detection of EBV associated disease are described. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：227 / 238

页数：12

共 114 条

[51] Quantitative analysis of Epstein-Barr virus load by using a real-time PCR assay [J].