The Silkworm Z Chromosome Is Enriched in Testis-Specific Genes

被引：69

作者：

Arunkumar, K. P. ^{[1
]}

Mita, Kazuei ^{[2
]}

Nagaraju, J. ^{[1
]}

机构：

[1] Ctr DNA Fingerprinting & Diagnost, Mol Genet Lab, Ctr Excellence Genet & Genom Silkmoths, Hyderabad 500001, Andhra Pradesh, India

[2] Natl Inst Agrobiol Sci, Tsukuba, Ibaraki 3058634, Japan

来源：

GENETICS | 2009年 / 182卷 / 02期

关键词：

SEX-BIASED GENES; X-CHROMOSOME; BOMBYX-MORI; DOMESTICATED SILKWORM; EXPRESSION PROFILES; LINKED GENES; EVOLUTION; SELECTION; GENOME; TRANSCRIPTOME;

D O I：

10.1534/genetics.108.099994

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The role of sex chromosomes in sex determination has been well studied in diverse groups of organisms. However, the role of the genes oil the sex chromosomes in conferring sexual dimorphism is still being experimentally evaluated. An unequal complement of sex chromosomes between two sexes makes them amenable to sex-specific evolutionary forces. Sex-linked genes preferentially expressed in one sex over the other offer a potential means of addressing the role of sex chromosomes in sexual dimorphism. We examined the testis transcriptome of the silkworm, Bombyx mori, which has a ZW chromosome constitution in the female and ZZ in the male, and show that file Z chromosome harbors a significantly higher number of genes expressed preferentially in testis compared to the autosomes. We hypothesize that sexual antagonism and absence of dosage compensation have possibly led to the accumulation of many male-specific genes oil the Z chromosome. Further, our analysis of testis-specific paralogous genes suggests that the accumulation oil the Z chromosome of genes advantageous to males has occurred primarily by translocation or tandem duplication.

引用

页码：493 / 501

页数：9

共 49 条

[41]

STEHR G, 1959, EVOLUTION, V13, P537, DOI 10.2307/2406135

[42] Nonrandom representation of sex-biased genes on chicken Z chromosome [J].

Storchova, R. ;

Divina, P. .

JOURNAL OF MOLECULAR EVOLUTION, 2006, 63 (05) :676-681

[43] Bm kettin, homologue of the Drosophila kettin gene, is located on the Z chromosome in Bombyx mori and is not dosage compensated [J].

Suzuki, MG ;

Shimada, T ;

Kobayashi, M .

HEREDITY, 1999, 82 (2) :170-179

[44] Absence of dosage compensation at the transcription level of a sex-linked gene in a female heterogametic insect, Bombyx mori [J].

Suzuki, MG ;

Shimada, T ;

Kobayashi, M .

HEREDITY, 1998, 81 (3) :275-283

[45]

Urushihara Hideko, 2006, V346, P31

[46] How mammalian sex chromosomes acquired their peculiar gene content [J].

Vallender, EJ ;

Lahn, BT .

BIOESSAYS, 2004, 26 (02) :159-169

[47] An abundance of X-linked genes expressed in spermatogonia [J].

Wang, PJ ;

McCarrey, JR ;

Yang, F ;

Page, DC .

NATURE GENETICS, 2001, 27 (04) :422-426

[48] Microarray-based gene expression profiles in multiple tissues of the domesticated silkworm, Bombyx mori [J].

Xia, Qingyou ;

Cheng, Daojun ;

Duan, Jun ;

Wang, Genhong ;

Cheng, Tingcai ;

Zha, Xingfu ;

Liu, Chun ;

Zhao, Ping ;

Dai, Fangyin ;

Zhang, Ze ;

He, Ningjia ;

Zhang, Liang ;

Xiang, Zhonghuai .

GENOME BIOLOGY, 2007, 8 (08)

[49] A draft sequence for the genome of the domesticated silkworm (Bombyx mori) [J].

Xia, QY ;

Zhou, ZY ;

Lu, C ;

Cheng, DJ ;

Dai, FY ;

Li, B ;

Zhao, P ;

Zha, XF ;

Cheng, TC ;

Chai, CL ;

Pan, GQ ;

Xu, JS ;

Liu, C ;

Lin, Y ;

Qian, JF ;

Hou, Y ;

Wu, ZL ;

Li, GR ;

Pan, MH ;

Li, CF ;

Shen, YH ;

Lan, XQ ;

Yuan, LW ;

Li, T ;

Xu, HF ;

Yang, GW ;

Wan, YJ ;

Zhu, Y ;

Yu, MD ;

Shen, WD ;

Wu, DY ;

Xiang, ZH ;

Yu, J ;

Wang, J ;

Li, RQ ;

Shi, JP ;

Li, H ;

Li, GY ;

Su, JN ;

Wang, XL ;

Li, GQ ;

Zhang, ZJ ;

Wu, QF ;

Li, J ;

Zhang, QP ;

Wei, N ;

Xu, JZ ;

Sun, HB ;

Dong, L ;

Liu, DY .

SCIENCE, 2004, 306 (5703) :1937-1940

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