Caged RNase: Photoactivation of the enzyme from perfect off-state by site-specific incorporation of 2-nitrobenzyl moiety

被引：24

作者：

Hiraoka, T ^{[1
]}

Hamachi, I ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Engn, Dept Chem & Biochem, Inst Fundamental Res Organ Chem, Fukuoka 8128581, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(02)00825-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Photo-triggered activation of semisynthetic Ribonuclease S' from a perfect off state was successfully carried out by incorporation of photo-labile caged moiety into a proximity to the active site. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：13 / 15

页数：3

共 21 条

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