Proinflammatory Cytokine Effects on Mesenchymal Stem Cell Therapy for the Ischemic Heart

被引：79

作者：

Abarbanell, Aaron M.

Coffey, Arthur C.

Fehrenbacher, John W.

Beckman, Daniel J.

Herrmann, Jeremy L.

Weil, Brent

Meldrum, Daniel R.

机构：

[1] Indiana Univ, Sch Med, Dept Surg, Methodist Hosp,Dept Cellular & Integrat Physiol, Indianapolis, IN 46202 USA

[2] Indiana Univ, Sch Med, Ctr Immunobiol, Indianapolis, IN USA

来源：

ANNALS OF THORACIC SURGERY | 2009年 / 88卷 / 03期

基金：

美国国家卫生研究院;

关键词：

TUMOR-NECROSIS-FACTOR; ACUTE MYOCARDIAL-INFARCTION; ENDOTHELIAL GROWTH-FACTOR; STROMAL CELLS; BONE-MARROW; TNF-ALPHA; IN-VITRO; INTRAMYOCARDIAL INJECTION; INTERNATIONAL-SOCIETY; PROGENITOR CELLS;

D O I：

10.1016/j.athoracsur.2009.02.093

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Mesenchymal stem cells (MSCs) hold great promise for improving myocardial recovery after ischemia. The cardiothoracic surgeon is uniquely positioned to be at the forefront of any clinical application of this therapy. As such, a basic understanding of stem cells and the cytokines that affect stem cell function will be an essential component of the surgeon's ever-expanding knowledge base. This review provides: (1) a general overview of stem cells and MSCs in particular, (2) critically analyzes several cytokines known to alter MSC function, and (3) discusses methods to manipulate cytokine-activated MSCs to improve MSC function for potential clinical application. (Ann Thorac Surg 2009;88:1036-43) (C) 2009 by The Society of Thoracic Surgeons

引用

页码：1036 / 1043

页数：8

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