Mobile Phone Use and Risk of Tumors: A Meta-Analysis

被引:85
作者
Myung, Seung-Kwon
Ju, Woong
McDonnell, Diana D.
Lee, Yeon Ji
Kazinets, Gene
Cheng, Chih-Tao
Moskowitz, Joel M.
机构
[1] Natl Canc Ctr, Natl Canc Control Res Inst, Canc Prevent Div, Goyang, South Korea
[2] Ewha Womans Univ, Sch Med, Dept Obstet & Gynecol, Seoul, South Korea
[3] Seoul Natl Univ Hosp, Dept Family Med, Seoul 110744, South Korea
[4] Univ Calif Berkeley, Sch Publ Hlth, Ctr Family & Community Hlth, Berkeley, CA 94720 USA
关键词
CELLULAR-TELEPHONE USE; RAT-BRAIN CELLS; INTERPHONE STUDY-GROUP; NORTH EUROPEAN COUNTRIES; CORDLESS TELEPHONES; ACOUSTIC NEUROMA; ELECTROMAGNETIC-FIELD; POOLED ANALYSIS; INTRACRANIAL TUMORS; IONIZING-RADIATION;
D O I
10.1200/JCO.2008.21.6366
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose Case-control studies have reported inconsistent findings regarding the association between mobile phone use and tumor risk. We investigated these associations using a meta-analysis. Methods We searched MEDLINE (PubMed), EMBASE, and the Cochrane Library in August 2008. Two evaluators independently reviewed and selected articles based on predetermined selection criteria. Results Of 465 articles meeting our initial criteria, 23 case-control studies, which involved 37,916 participants (12,344 patient cases and 25,572 controls), were included in the final analyses. Compared with never or rarely having used a mobile phone, the odds ratio for overall use was 0.98 for malignant and benign tumors (95% CI, 0.89 to 1.07) in a random-effects meta-analysis of all 23 studies. However, a significant positive association (harmful effect) was observed in a random-effects meta-analysis of eight studies using blinding, whereas a significant negative association (protective effect) was observed in a fixed-effects meta-analysis of 15 studies not using blinding. Mobile phone use of 10 years or longer was associated with a risk of tumors in 13 studies reporting this association (odds ratio = 1.18; 95% CI, 1.04 to 1.34). Further, these findings were also observed in the subgroup analyses by methodologic quality of study. Blinding and methodologic quality of study were strongly associated with the research group. Conclusion The current study found that there is possible evidence linking mobile phone use to an increased risk of tumors from a meta-analysis of low-biased case-control studies. Prospective cohort studies providing a higher level of evidence are needed.
引用
收藏
页码:5565 / 5572
页数:8
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