Bioactive "self-sensing" optical systems

被引：46

作者：

Domachuk, Peter ^{[1
]}

Perry, Hannah ^{[1
]}

Amsden, Jason J. ^{[1
]}

Kaplan, David L. ^{[1
]}

Omenetto, Fiorenzo G. ^{[1
,2
]}

机构：

[1] Tufts Univ, Dept Biomed Engn, Medford, MA 02155 USA

[2] Tufts Univ, Dept Phys, Medford, MA 02155 USA

来源：

APPLIED PHYSICS LETTERS | 2009年 / 95卷 / 25期

关键词：

MICROFLUIDIC DEVICES; SILK; OPTOFLUIDICS; INSECTS; SPIDERS;

D O I：

10.1063/1.3275719

中图分类号：

O59 [应用物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

Free-standing silk films are useful materials to manufacture nanopatterned optical elements and to immobilize bio-dopants such as enzymes while maintaining their biological activity. These traits were combined by incorporating hemoglobin into free-standing silk diffraction gratings to fabricate chemically responsive optofluidic devices responsive to ambient gas conditions, constituting a simple oxygen sensor. This type of self-analyzing optical system is enabled by the unique ability to reproduce high-fidelity optical structures in silk while maintaining the activity of entrapped proteins such as hemoglobin. These bioactive optical devices offer a direct readout capability, adding utility into the bioresponsive material arena. (C) 2009 American Institute of Physics. [doi:10.1063/1.3275719]

引用

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