The facile production of N-methyl amino acids via oxazolidinones

被引：55

作者：

Aurelio, L ^{[1
]}

Brownlee, RTC ^{[1
]}

Hughes, AB ^{[1
]}

Sleebs, BE ^{[1
]}

机构：

[1] La Trobe Univ, Dept Chem, Bundoora, Vic 3083, Australia

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2000年 / 53卷 / 05期

关键词：

oxazolidinones; N-methyl amino acids; synthesis; reductive cleavage;

D O I：

10.1071/CH99082

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A range of oxazolidinones derived from N-carbamoyl alpha-amino acids were prepared by an efficient method as key intermediates in the synthesis of N-methyl amino acids and peptides. The method was readily applied to most alpha-amino acids except those with basic side chains. The oxazolidinones were converted by reductive cleavage into N-methyl alpha-amino acids.

引用

页码：425 / 433

页数：9

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