Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes

被引：65

作者：

Collie, Gavin ^{[1
]}

Reszka, Anthony P. ^{[1
]}

Haider, Shozeb M. ^{[1
]}

Gabelica, Valerie ^{[2
]}

Parkinson, Gary N. ^{[1
]}

Neidle, Stephen ^{[1
]}

机构：

[1] Univ London, Canc Res UK Biomol Struct Grp, Sch Pharm, London WC1N 1AX, England

[2] Univ Liege, Mass Spectrometry Lab, GIGA Res, B-4000 Liege, Belgium

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 48期

关键词：

ELECTROSPRAY MASS-SPECTROMETRY; REPEAT-CONTAINING RNA; K+ SOLUTION; NRAS PROTOONCOGENE; EUKARYOTIC CELLS; NUCLEIC-ACIDS; HIGHER-ORDER; C-MYC; TRANSLATION; DRUG;

D O I：

10.1039/b901889a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Quadruplex RNAs are less well understood than their DNA counterparts, yet of potentially high biological relevance. The interactions of several quadruplex-binding ligands with telomeric RNA quadruplexes are reported and compared with their binding to the analogous DNA quadruplexes.

引用

收藏

页码：7482 / 7484

页数：3

相关论文

共 45 条

[1] Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution [J].

Ambrus, Attila ;

Chen, Ding ;

Dai, Jixun ;

Bialis, Tiffanie ;

Jones, Roger A. ;

Yang, Danzhou .

NUCLEIC ACIDS RESEARCH, 2006, 34 (09) :2723-2735

[2] Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif [J].

Arora, Amit ;

Dutkiewicz, Mariola ;

Scaria, Vinod ;

Hariharan, Manoj ;

Maiti, Souvik ;

Kurreck, Jens .

RNA, 2008, 14 (07) :1290-1296

[3] Telomeric repeat-containing RNA and RNA surveillance factors at mammalian chromosome ends [J].

Azzalin, Claus M. ;

Reichenbach, Patrick ;

Khoriauli, Lela ;

Giulotto, Elena ;

Lingner, Joachim .

SCIENCE, 2007, 318 (5851) :798-801

[4] Quadruplex DNA: sequence, topology and structure [J].

Burge, Sarah ;

Parkinson, Gary N. ;

Hazel, Pascale ;

Todd, Alan K. ;

Neidle, Stephen .

NUCLEIC ACIDS RESEARCH, 2006, 34 (19) :5402-5415

[5] The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function [J].

Burger, AM ;

Dai, FP ;

Schultes, CM ;

Reszka, AP ;

Moore, MJ ;

Double, JA ;

Neidle, S .

CANCER RESEARCH, 2005, 65 (04) :1489-1496

[6] Structural basis of DNA quadruplex recognition by an acridine drug [J].

Campbell, Nancy H. ;

Parkinson, Gary N. ;

Reszka, Anthony P. ;

Neidle, Stephen .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (21) :6722-+

[7] Antitumor polycyclic acridines. 20. search for DNA quadruplex binding selectivity in a series of 8,13-dimethylquino[4,3,2-kl]acridinium salts: Telomere-targeted agents [J].

Cheng, Mai-Kim ;

Modi, Chetna ;

Cookson, Jennifer C. ;

Hutchinson, Ian ;

Heald, Robert A. ;

McCarroll, Andrew J. ;

Missailidis, Sotiris ;

Tanious, Farial ;

Wilson, W. David ;

Mergny, Jean-Louis ;

Laughton, Charles A. ;

Stevens, Malcolm F. G. .

JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (04) :963-975

[8] A 2ND GENERATION FORCE-FIELD FOR THE SIMULATION OF PROTEINS, NUCLEIC-ACIDS, AND ORGANIC-MOLECULES [J].

CORNELL, WD ;

CIEPLAK, P ;

BAYLY, CI ;

GOULD, IR ;

MERZ, KM ;

FERGUSON, DM ;

SPELLMEYER, DC ;

FOX, T ;

CALDWELL, JW ;

KOLLMAN, PA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (19) :5179-5197

[9] Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands [J].

Cuenca, Francisco ;

Greciano, Olga ;

Gunaratnam, Mekala ;

Haider, Shozeb ;

Munnur, Deeksha ;

Nanjunda, Rupesh ;

Wilson, W. David ;

Neidle, Stephen .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (05) :1668-1673

[10] Targeting telomeres and telomerase [J].

De Cian, Anne ;

Lacroix, Laurent ;

Douarre, Celine ;

Temime-Smaali, Nassima ;

Trentesaux, Chantal ;

Riou, Jean-Francois ;

Mergny, Jean-Louis .

BIOCHIMIE, 2008, 90 (01) :131-155

← 1 2 3 4 5 →