Flavonoids can replace α-tocopherol as an antioxidant

被引：223

作者：

van Acker, FAA

Schouten, O

Haenen, GRMM

van der Vijgh, WJF

Bast, A

机构：

[1] Vrije Univ Amsterdam, Univ Hosp, Dept Med Oncol, NL-1081 HV Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Fac Chem, Dept Pharmacochem, LACDR, NL-1081 HV Amsterdam, Netherlands

[3] Univ maastricht, Dept Pharmacol & Toxicol, NL-6200 MD Maastricht, Netherlands

来源：

FEBS LETTERS | 2000年 / 473卷 / 02期

关键词：

lipid peroxidation; alpha-tocopherol; glutathione; flavonoid; antioxidant; free radical reductase;

D O I：

10.1016/S0014-5793(00)01517-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endogenous antioxidants such as the lipid-soluble vitamin E protect the cell membranes from oxidative damage. Glutathione seems to be able to regenerate alpha-tocopherol via a so-called free radical reductase, The transient protection by reduced glutathione (GSH) against lipid peroxidation in control liver microsomes is not observed in microsomes deficient in alpha-tocopherol. Introduction of antioxidant flavonoids, such as 7-monohydroxyethylrutoside, fisetin or naringenin, into the deficient microsomes restored the GSH-dependent protection, suggesting that flavonoids can take over the role of alpha-tocopherol as a chain-breaking antioxidant in liver microsomal membranes. (C) 2000 Federation of European Biochemical Societies.

引用

页码：145 / 148

页数：4

共 21 条

[1] THE WIDELY USED ANESTHETIC AGENT PROPOFOL CAN REPLACE ALPHA-TOCOPHEROL AS AN ANTIOXIDANT [J].