The critical role of nucleus accumbens dopamine systems in the mediation of fixed interval schedule-controlled operant behavior

被引：32

作者：

CorySlechta, DA

Pazmino, R

Bare, C

机构：

[1] Dept. of Neurobiology and Anatomy, Univ. of Rochester Medical School, Rochester, NY 14642

来源：

BRAIN RESEARCH | 1997年 / 764卷 / 1-2期

关键词：

fixed interval schedule; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; dopamine; nucleus accumbens; dorsal striatum; operant; behavior;

D O I：

10.1016/S0006-8993(97)00591-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microinjections of the irreversible dopamine antagonist EEDQ ( N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline), into nucleus accumbens but not into dorsal striatum, markedly decreased response rates on a fixed interval schedule of reinforcement. These preferential effects in nucleus accumbens could be prevented by selectively activating either D-1 or D-2 receptors. These data demonstrate a critical role for mesolimbic dopamine systems in the mediation of fixed interval schedule-controlled operant behavior. (C) 1997 Elsevier Science B.V.

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收藏

页码：253 / 256

页数：4

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