The world of subinhibitory antibiotic concentrations

被引：543

作者：

Davies, Julian ^{[1
]}

Spiegelman, George B. ^{[1
]}

Yim, Grace ^{[1
]}

机构：

[1] Univ British Columbia, Dept Microbiol & Immunol, Inst Life Sci, Vancouver, BC V6T 01Z3, Canada

来源：

CURRENT OPINION IN MICROBIOLOGY | 2006年 / 9卷 / 05期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

D O I：

10.1016/j.mib.2006.08.006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Although antibiotics have long been known to have multiple effects on bacterial cells at low concentrations, it is only with the advent of genome transcription analyses that these activities have been studied in detail at the level of cell metabolism. It has been shown that all antibiotics, regardless of their receptors and mode of action, exhibit the phenomenon of hormesis and provoke considerable transcription activation at low concentrations. These analyses should be of value in providing information on antibiotic side-effects, in bioactive natural product discovery and antibiotic mode-of-action studies.

引用

页码：445 / 453

页数：9

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