Mitotic spindle morphogenesis: Ran on the microtubule cytoskeleton and beyond

被引：30

作者：

Goodman, B.

Zheng, Y. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Carnegie Inst Washington, Dept Biol, Baltimore, MD 21218 USA

[3] Howard Hughes Med Inst, Baltimore, MD 21218 USA

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2006年 / 34卷

关键词：

aurora A; importin; microtubule; mitosis; Ran; spindle;

D O I：

10.1042/BST0340716

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Assembly and disassembly of the mitotic spindle are essential for both chromosome segregation and cell division. The small G-protein Ran has emerged as an important regulator of spindle assembly. In this review, we look at the role of Ran in different aspects of spindle assembly, including its effects on microtubule assembly dynamics and microtubule organization. In addition, we examine the possibility of a spindle matrix and the role Ran might play in such a structure.

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页码：716 / 721

页数：6

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