Spatial coordination of spindle assembly by chromosome-mediated signaling gradients

被引：222

作者：

Caudron, M

Bunt, G

Bastiaens, P ^{[1
]}

Karsenti, E

机构：

[1] European Mol Biol Lab, Cell Biol & Biophys Dept, D-69117 Heidelberg, Germany

[2] Max Planck Inst Expt Med, D-37075 Gottingen, Germany

来源：

SCIENCE | 2005年 / 309卷 / 5739期

关键词：

D O I：

10.1126/science.1115964

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

During cell division, chromosomes are distributed to daughter cells by the mitotic spindle. This system requires spatial cues to reproducibly self-organize. We report that such cues are provided by chromosome-mediated interaction gradients between the small guanosine triphosphatase (GTPase) Ran and importin-beta. This produces activity gradients that determine the spatial distribution of microtubule nucleation and stabilization around chromosomes and that are essential for the self-organization of microtubules into a bipolar spindle.

引用

页码：1373 / 1376

页数：4

共 26 条

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