CHEMICAL BIOLOGY A Notch above other inhibitors

被引：23

作者：

Arora, Paramjit S. ^{[1
]}

Ansari, Aseem Z. ^{[2
,3
]}

机构：

[1] NYU, Dept Chem, New York, NY 10003 USA

[2] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

[3] Univ Wisconsin, Genome Ctr, Madison, WI 53706 USA

来源：

NATURE | 2009年 / 462卷 / 7270期

关键词：

CANCER-THERAPY; ACTIVATION; APOPTOSIS; PEPTIDES;

D O I：

10.1038/462171a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

A tenet of drug discovery states that molecules greater than a certain size don't enter cells. But not only do certain synthetic peptides refute this idea, they also inhibit 'undruggable' biological targets.

引用

页码：171 / +

页数：2

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