Linkers and cleavage strategies in solid-phase organic synthesis and combinatorial chemistry

被引：549

作者：

Guillier, F

Orain, D

Bradley, M ^{[1
]}

机构：

[1] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England

[2] Agouron Pharmaceut, Alanex Div, San Diego, CA 92121 USA

来源：

CHEMICAL REVIEWS | 2000年 / 100卷 / 06期

关键词：

D O I：

10.1021/cr980040+

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

To date, a number of papers have addressed the use of polymeric supports in organic synthesis. This article presents a comprehensive review that demonstrates the vast literature, both old and modern, associated with linker chemistries. For purposes of clarity, linkers are classified into two types: integral linkers, and nonintegral (or grafted) linkers.

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页码：2091 / 2157

页数：67

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